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- 2019
Mesenchymal Niche-Specific Expression of Cxcl12 Controls Quiescence of Treatment-Resistant Leukemia Stem CellsDOI: https://doi.org/10.1016/j.stem.2019.02.018 Abstract: ？ CXCL12 deletion from mesenchymal stromal cells (MSCs) expands leukemia stem cells ？ LSCs undergo increased self-renewing divisions, related to enhanced EZH2 activity ？ CXCL12 deletion from MSCs increases LSC elimination by TKI treatment ？ CXCL12+ MSC niches are critical for maintaining quiescent, TKI-resistant LSC
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