%0 Journal Article
%T Mesenchymal Niche-Specific Expression of Cxcl12 Controls Quiescence of Treatment-Resistant Leukemia Stem Cells
%J -
%D 2019
%R https://doi.org/10.1016/j.stem.2019.02.018
%X £¿ CXCL12 deletion from mesenchymal stromal cells (MSCs) expands leukemia stem cells £¿ LSCs undergo increased self-renewing divisions, related to enhanced EZH2 activity £¿ CXCL12 deletion from MSCs increases LSC elimination by TKI treatment £¿ CXCL12+ MSC niches are critical for maintaining quiescent, TKI-resistant LSC
%U https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(19)30070-0