Aging-like Spontaneous Epigenetic Silencing Facilitates Wnt Activation, Stemness, and BrafV600E-Induced Tumorigenesis

？ It takes 5 months to transform young, proximal colon organoids by Braf V600E mutation ？ Transformed Braf V600E organoids acquire CIMP, affecting Wnt and differentiation genes ？ Spontaneous CIMP evolution in aging wild-type organoids promotes transformation ？ Deletion of key CIMP genes causes rapid Braf V600E-induced transformatio