%0 Journal Article
%T Aging-like Spontaneous Epigenetic Silencing Facilitates Wnt Activation, Stemness, and BrafV600E-Induced Tumorigenesis
%J -
%D 2019
%R https://doi.org/10.1016/j.ccell.2019.01.005
%X £¿ It takes 5 months to transform young, proximal colon organoids by Braf V600E mutation £¿ Transformed Braf V600E organoids acquire CIMP, affecting Wnt and differentiation genes £¿ Spontaneous CIMP evolution in aging wild-type organoids promotes transformation £¿ Deletion of key CIMP genes causes rapid Braf V600E-induced transformatio
%U https://www.cell.com/cancer-cell/fulltext/S1535-6108(19)30039-X