Becalming Type 17 Inflammation in Ulcerative Colitis

Genome-wide association studies in ulcerative colitis point to a role for FcγRIIA, a receptor for IgG. Castro-Dopico et al. (2019) Castro-Dopico T. Dennison T.W. Ferdinand J.R. Mathews R.J. Fleming A. Clift D. Stewart B.J. Jing C. Strongili K. Labzin L.I. et al. Anti-commensal IgG Drives Intestinal Inflammation and Type 17 Immunity in Ulcerative Colitis. Immunity. 2019; 50 ( this issue) : 1099-1114 Abstract Full Text Full Text PDF PubMed Scopus (1) Google Scholar find a profound induction of anti-commensal IgG in the colonic mucosa of UC patients and outline a pathway whereby FcγR activation by IgG triggers IL-1β production, type 17 immunity, and the exacerbation of inflammation