%0 Journal Article
%T Becalming Type 17 Inflammation in Ulcerative Colitis
%J -
%D 2019
%R https://doi.org/10.1016/j.immuni.2019.03.019
%X Genome-wide association studies in ulcerative colitis point to a role for Fc¦ÃRIIA, a receptor for IgG. Castro-Dopico et al. (2019) Castro-Dopico T. Dennison T.W. Ferdinand J.R. Mathews R.J. Fleming A. Clift D. Stewart B.J. Jing C. Strongili K. Labzin L.I. et al. Anti-commensal IgG Drives Intestinal Inflammation and Type 17 Immunity in Ulcerative Colitis. Immunity. 2019; 50 ( this issue) : 1099-1114 Abstract Full Text Full Text PDF PubMed Scopus (1) Google Scholar find a profound induction of anti-commensal IgG in the colonic mucosa of UC patients and outline a pathway whereby Fc¦ÃR activation by IgG triggers IL-1¦Â production, type 17 immunity, and the exacerbation of inflammation
%U https://www.cell.com/immunity/fulltext/S1074-7613(19)30136-0