Structural Insights into Stimulation of Ash1L's H3K36 Methyltransferase Activity through Mrg15 Binding

？ We solved the crystal structure of hAsh1L bound to Mrg15 ？ hAsh1L interacts with Mrg15 mainly via an N-terminal extension ？ The autoinhibitory loop of hAsh1L is disordered upon Mrg15 binding ？ Mrg15 binding induces displacement of SA