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-  2019 

X-Ray Structure of Human Sulfide:Quinone Oxidoreductase: Insights into the Mechanism of Mitochondrial Hydrogen Sulfide Oxidation

DOI: https://doi.org/10.1016/j.str.2019.03.002

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Abstract:

? A hydrophilic H 2S-oxidizing site is connected to a hydrophobic tunnel that binds CoQ ? Cys201 is optimally positioned to form a postulated 4a-thiolate flavin intermediate ? A unique electropositive depression serves as a binding site for sulfane acceptors ? This hollow may also funnel negatively charged substrates to the H 2S-oxidizing sit

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