Absence of Cytosolic 2-Cys Prx Subtypes I and II Exacerbates TNF-α-Induced Apoptosis via Different Routes

？ Absence of Prx I and Prx II exacerbates TNF-α-induced apoptosis in cancer cells. ？ Prx I binds histone H2AX and inhibits DNA damage-dependent apoptosis. ？ Prx II binds and prevents the oxidative activation of cIAP1 E3 ligase. ？ Absence of Prx II induces cell-autonomous apoptosis and inhibits tumor growth