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- 2019
ORP4L Extracts and Presents PIP2 from Plasma Membrane for PLCβ3 Catalysis: Targeting It Eradicates Leukemia Stem CellsDOI: https://doi.org/10.1016/j.celrep.2019.01.082 Abstract: ？ ORP4L is highly expressed in LSCs and essential for LSC survival ？ ORP4L extracts and presents PIP2 from the plasma membrane for PLCβ3 catalysis in LSCs ？ LYZ-81 is identified as a specific inhibitor of ORP4L ？ Targeting ORP4L by LYZ-81 selectively eradicates LSC
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