%0 Journal Article
%T ORP4L Extracts and Presents PIP2 from Plasma Membrane for PLC¦Â3 Catalysis: Targeting It Eradicates Leukemia Stem Cells
%J -
%D 2019
%R https://doi.org/10.1016/j.celrep.2019.01.082
%X £¿ ORP4L is highly expressed in LSCs and essential for LSC survival £¿ ORP4L extracts and presents PIP2 from the plasma membrane for PLC¦Â3 catalysis in LSCs £¿ LYZ-81 is identified as a specific inhibitor of ORP4L £¿ Targeting ORP4L by LYZ-81 selectively eradicates LSC
%U https://www.cell.com/cell-reports/fulltext/S2211-1247(19)30111-1