Transient Kinetic Analysis of SWR1C-Catalyzed H2A.Z Deposition Unravels the Impact of Nucleosome Dynamics and the Asymmetry of Histone Exchange

？ SWR1C catalyzes two cycles of H2A.Z deposition by a biphasic, asymmetric reaction ？ Binding of SWR1C enhances nucleosome dynamics ？ Initial eviction of an H2A-H2B dimer involves ATP-dependent histone-DNA unwrapping ？ Nucleosomal DNA sequence can modulate the rate of H2A.Z exchang