Mitochondrial control region and GSTP1 polymorphism associated with familial urinary bladder cancer in Karbi-Anglong tribe of Assam, Northeast India

Keywords: In the present study, we evaluated the mutations in GSTP1 and mitochondrial D-loop genes in two unrelated familial bladder cancer patients belonging to Karbi Anglong Assam tribe. Mitochondrial D-loop and nuclear GSTP1 polymorphic region were amplified and sequenced for all the family members and patients. Two SNPs in the GSTP1 gene for amino acid substitutions at codons 105 (Ile →Val) and 114 (Val →Ala) were genotyped by PCR-RFLP-based methods.

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Abstract:

Background: Multiple studies have suggested that subjects with glutathione S-transferase P1 (GSTP1)-mutations are at high risk for urinary bladder cancer (UBC).

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