%0 Journal Article
%T Mitochondrial control region and GSTP1 polymorphism associated with familial urinary bladder cancer in Karbi-Anglong tribe of Assam, Northeast India
%A Felix Jakha
%A Hanumath Singh Rathore
%A K. Toska Sumi
%A Keheibamding Thou
%A Nachimuthu Senthil Kumar
%A Ravi Prakash Yadav
%A Souvik Ghatak
%A Zothan Sanga
%J -
%D 2017
%X Background: Multiple studies have suggested that subjects with glutathione S-transferase P1 (GSTP1)-mutations are at high risk for urinary bladder cancer (UBC).
%K In the present study
%K we evaluated the mutations in GSTP1 and mitochondrial D-loop genes in two unrelated familial bladder cancer patients belonging to Karbi Anglong Assam tribe. Mitochondrial D-loop and nuclear GSTP1 polymorphic region were amplified and sequenced for all the family members and patients. Two SNPs in the GSTP1 gene for amino acid substitutions at codons 105 (Ile ˇúVal) and 114 (Val ˇúAla) were genotyped by PCR-RFLP-based methods.
%U https://www.ajol.info/index.php/ejhg/article/view/152206