盐酸埃克替尼对ACC-M细胞MMP-2、E-cadherin蛋白表达的影响
Influence of Icotinib Hydrochloride uPon the Protein ExPression of ACC-M Cells MMP-2 and E-cadherin

盐酸埃克替尼是一种表皮生长因子受体酪氨酸激酶抑制剂，利用免疫细胞化学方法和间接免疫荧光联合流式细胞技术，检测它在体外对人涎腺腺样囊性癌细胞株（ACC-M）MMP-2、E-cadherin 蛋白表达的影响。结果表明：盐酸埃克替尼可降低 MMP-2蛋白表达，增加 E-cadherin 蛋白表达，可抑制人涎腺腺样囊性癌 ACC-M 细胞的浸润、转移。
Icotinib hydrochloride is a kind of epidermal growth factor receptor tyrosine kinase inhibitor,whose influ-ence upon the protein expression of ACC-M cells MMP-2 and E-cadherin can be tested by way of immunocytochem-istry and the technique of indirect immunofluorescence together with flow cytometry. The results show that icotinib hydrochloride can reduce the protein expression of MMP-2,but increase that of E-cadherin,thus it can be used to restrain the infiltration and metastasis of ACC-M cells