%0 Journal Article
%T 盐酸埃克替尼对ACC-M细胞MMP-2、E-cadherin蛋白表达的影响<br>Influence of Icotinib Hydrochloride uPon the Protein ExPression of ACC-M Cells MMP-2 and E-cadherin
%A 杨彩玲
%A 韩金红
%A 王伟新
%A 崔卫刚
%J -
%D 2014
%X 盐酸埃克替尼是一种表皮生长因子受体酪氨酸激酶抑制剂，利用免疫细胞化学方法和间接免疫荧光联合流式细胞技术，检测它在体外对人涎腺腺样囊性癌细胞株（ACC-M）MMP-2、E-cadherin 蛋白表达的影响。结果表明：盐酸埃克替尼可降低 MMP-2蛋白表达，增加 E-cadherin 蛋白表达，可抑制人涎腺腺样囊性癌 ACC-M 细胞的浸润、转移。<br>Icotinib hydrochloride is a kind of epidermal growth factor receptor tyrosine kinase inhibitor,whose influ-ence upon the protein expression of ACC-M cells MMP-2 and E-cadherin can be tested by way of immunocytochem-istry and the technique of indirect immunofluorescence together with flow cytometry. The results show that icotinib hydrochloride can reduce the protein expression of MMP-2,but increase that of E-cadherin,thus it can be used to restrain the infiltration and metastasis of ACC-M cells
%K 盐酸埃克替尼
%K ACC-M 细胞
%K MMP-2
%K E-cadherin<br>盐酸埃克替尼 ACC-M 细胞 MMP-2 E-cadherin
%K 盐酸埃克替尼 ACC-M 细胞 MMP-2 E-cadherin
%K 盐酸埃克替尼 ACC-M 细胞 MMP-2 E-cadherin
%K 盐酸埃克替尼 ACC-M 细胞 MMP-2 E-cadherin
%U http://lkxb.jxnu.edu.cn//oa/darticle.aspx?type=view&id=20140409