摘要 目的 提高临床医师对秋水仙碱中毒机制、临床症状、诊疗措施的认识。 方法 回顾性分析我院近期成功救治的1例口服超致死剂量秋水仙碱中毒患者的诊疗过程，并复习相关文献。 结果 患者，男，24岁，口服秋水仙碱90 mg（180片)，先后出现消化道症状、骨髓抑制、多脏器衰竭等临床表现，给予洗胃、导泻、血浆置换、连续肾脏替代疗法（CRRT）、成分输血、抗感染、营养心肌等一系列对症支持治疗后好转出院。 结论 秋水仙碱是临床常见药物，大剂量服用可出现严重中毒症状，致死率高，目前尚无特效解药，需早期积极对症处理。 Abstract：Objective To improve the understanding of the mechanism, clinical symptoms, and treatment measures of colchicine poisoning among clinicians. Methods A retrospective analysis was performed for the diagnosis and treatment of one patient with colchicine poisoning with a superlethal dose who was successfully rescued in our hospital, and a literature review was also performed. Results A 24 year-old male patient took 180 tablets of colchicine (90 mg) orally and then developed various clinical manifestations including digestive tract symptoms, myelosuppression, and multiple organ failure. The patient was given a series of symptomatic/supportive treatment, such as gastric lavage, catharsis, plasma exchange, continuous renal replacement therapy, component transfusion, anti-infective therapy, and myocardial nutrition, and then he was improved and discharged. Conclusion Colchicine is a commonly used drug in clinical practice. Large-dose colchicine can cause serious poisoning symptoms with a high mortality rate. At present, there is no specific antidote, and symptomatic treatment should be given as early as possible
