%0 Journal Article
%T 成功救治超致死剂量秋水仙碱中毒1例并文献复习
%A 杜忠彩　苏媛　刘玉　周欣蓓　山峰　边城
%J -
%D 2019
%R 10.13362/j.jpmed.201906020
%X 摘要 目的　提高临床医师对秋水仙碱中毒机制、临床症状、诊疗措施的认识。 方法　回顾性分析我院近期成功救治的1例口服超致死剂量秋水仙碱中毒患者的诊疗过程，并复习相关文献。 结果　患者，男，24岁，口服秋水仙碱90 mg（180片)，先后出现消化道症状、骨髓抑制、多脏器衰竭等临床表现，给予洗胃、导泻、血浆置换、连续肾脏替代疗法（CRRT）、成分输血、抗感染、营养心肌等一系列对症支持治疗后好转出院。 结论　秋水仙碱是临床常见药物，大剂量服用可出现严重中毒症状，致死率高，目前尚无特效解药，需早期积极对症处理。<br>Abstract：Objective　To improve the understanding of the mechanism, clinical symptoms, and treatment measures of colchicine poisoning among clinicians. Methods　A retrospective analysis was performed for the diagnosis and treatment of one patient with colchicine poisoning with a superlethal dose who was successfully rescued in our hospital, and a literature review was also performed. Results　A 24 year-old male patient took 180 tablets of colchicine (90 mg) orally and then developed various clinical manifestations including digestive tract symptoms, myelosuppression, and multiple organ failure. The patient was given a series of symptomatic/supportive treatment, such as gastric lavage, catharsis, plasma exchange, continuous renal replacement therapy, component transfusion, anti-infective therapy, and myocardial nutrition, and then he was improved and discharged. Conclusion　Colchicine is a commonly used drug in clinical practice. Large-dose colchicine can cause serious poisoning symptoms with a high mortality rate. At present, there is no specific antidote, and symptomatic treatment should be given as early as possible
%K 秋水仙碱
%K 药物过量
%K 中毒
%K 诊断
%K 治疗<br>Colchicine
%K Drug overdose
%K Poisoning
%K Diagnosis
%K Therapy
%U http://jpmed.qdu.edu.cn/CN/10.13362/j.jpmed.201906020