Liver and Diabetes: Molecular and Clinical Outcomes

This study is a follow of our previous studies in which we have shown that diabetes is a result of stress. Here, we may use the term "general pooling stress" instead of metabolic syndrome as will be demonstrated in following sections. The present study showed that diabetes type 1 has impacts on liver of diabetic rats through the induction of molecular changes through up-regulation of HSP90 and down-regulation of HSP70. Actually, our data support the idea of autoimmunity involvement in the pathogenesis of type 1 diabetes. Furthermore, when liver pathology is not addressed in diabetic cases, the chance to identify therapeutic targets is likely to be lacked. Liver plays a vital role in the development and pathogenesis of diabetes type-1 and it？？？？？？s therapeutic involvement is likely to improve the status of patients with this type of disease. Our results may form novel future research lines, particularly molecular therapeutic strategies.