%0 Journal Article
%T Liver and Diabetes: Molecular and Clinical Outcomes
%J -
%D 2019
%R 10.36648/molecularpathology.3.1.22
%X This study is a follow of our previous studies in which we have shown that diabetes is a result of stress. Here, we may use the term "general pooling stress" instead of metabolic syndrome as will be demonstrated in following sections. The present study showed that diabetes type 1 has impacts on liver of diabetic rats through the induction of molecular changes through up-regulation of HSP90 and down-regulation of HSP70.

Actually, our data support the idea of autoimmunity involvement in the pathogenesis of type 1 diabetes. Furthermore, when liver pathology is not addressed in diabetic cases, the chance to identify therapeutic targets is likely to be lacked.

Liver plays a vital role in the development and pathogenesis of diabetes type-1 and it£¿£¿£¿£¿£¿£¿s therapeutic involvement is likely to improve the status of patients with this type of disease. Our results may form novel future research lines, particularly molecular therapeutic strategies.
%K Ahed J Alkhatib
%K Diabetes type 1
%K Stress proteins
%K HSP70
%K HSP90
%K Up-regulation
%K Down-regulation
%U https://www.imedpub.com/abstract/liver-and-diabetes-molecular-and-clinical-outcomes-24718.html