The Potential of Non-Invasive Biochemical Testing Late Post-transplant in Prediction of Declining Kidney Allograft Function

Identification of kidney transplant recipients at risk for allograft failure late posttransplant is an unmet demand. Our aim was to determine the capacity of serum beta-2- microglobulin (2MG), serum and urinary interleukins (IL-2, IL-10 and IL-8) and enzymes (γ-glutamyl transpeptidase, alkaline phosphatase, alanine aminotransferase [ALT], aspartate aminotransferase [AST], and N-acetyl-β-Dhexosaminidase [NAG]) in the late posttransplant period to predict a deterioration of kidney allograft function. Several non-invasive biomarkers predicted certain (serum 2MG, urinary IL-2 and AST), and rapid (urinary IL-2 and AST) drop of glomerular filtration rate over two years. We are standing on underestimated potential of non-invasive biochemical testing in kidney transplant setting.