受体酪氨酸激酶抑制剂Dovitinib的合成
The Synthesis of Tyosine Kinase Inhibitor Dovitinib

5-氟-2-硝基苯胺经N-甲基哌嗪取代,氢气还原,与3-乙氧基-3-亚氨基丙酸乙酯盐酸盐环合,最后与2-氨基-6-氟苯腈反应得Dovitinib,产物收率为43.6；,液相纯度达99.53；.目标产物结构经氢谱、质谱证实.
By substituting 5-chloro-2-nitroaniline by N-methylpiperazine and reduced eby hydrogen,dovitinib is obtained via two cyclizations.The target product structure is confirmed by hydrogen spectrum,mass spectrometry with yield 43%,and liquid purity to 99.53%