Dihydrobenzofuran clubbed benzimidazole having benzothiazole derivatives as potential anthelmintic and antitubercular agents

In the present communication, a series of novel N-(2-((benzo[d]thiazol-2-ylthio)methyl)-1-benzyl-1H-benzo[d] imidazol-6-yl)aryl benzamides(6a-l) and 4-amino-N-(2-((benzo[d]thiazol-2-ylthio) methyl)-1-benzyl-1H-benzo [d]imidazol-6-yl)-5-substituted-2,3-dihydrobenzofuran-7-carboxamides(7a-b) were efficiently synthesized and evaluated for their in vitro anthelmintic and antitubercular activity against Indian earthworms (Pheretimaposthuma) and M. tuberculosis H37Rv strains. The results of biological study revealed that compounds6b-c, 6g, 6k and 7a-b inhibited excellent anthelmintic activity in the range of 1:45-9:35 and 1:05-8:05 mean paralyzing, while compounds6b-c, 6f-h 6k and 7a-b awarded with inductively electron withdrawing chlorine and electron donating methyl groups afforded maximum MICs ranging from 1.81 to 10.92 μM against Mtb. Compounds 7b and 6k possessed highest inhibition at MIC of 1.81 & 2.1 μM. All the newly synthesized analogues were characterized by IR, 1H NMR, 13CNMR and mass spectroscopic techniques