%0 Journal Article
%T Dihydrobenzofuran clubbed benzimidazole having benzothiazole derivatives as potential anthelmintic and antitubercular agents
%A Mayank R. Mehta
%J -
%D 2015
%X In the present communication, a series of novel N-(2-((benzo[d]thiazol-2-ylthio)methyl)-1-benzyl-1H-benzo[d] imidazol-6-yl)aryl benzamides(6a-l) and 4-amino-N-(2-((benzo[d]thiazol-2-ylthio) methyl)-1-benzyl-1H-benzo [d]imidazol-6-yl)-5-substituted-2,3-dihydrobenzofuran-7-carboxamides(7a-b) were efficiently synthesized and evaluated for their in vitro anthelmintic and antitubercular activity against Indian earthworms (Pheretimaposthuma) and M. tuberculosis H37Rv strains. The results of biological study revealed that compounds6b-c, 6g, 6k and 7a-b inhibited excellent anthelmintic activity in the range of 1:45-9:35 and 1:05-8:05 mean paralyzing, while compounds6b-c, 6f-h 6k and 7a-b awarded with inductively electron withdrawing chlorine and electron donating methyl groups afforded maximum MICs ranging from 1.81 to 10.92 ¦ÌM against Mtb. Compounds 7b and 6k possessed highest inhibition at MIC of 1.81 & 2.1 ¦ÌM. All the newly synthesized analogues were characterized by IR, 1H NMR, 13CNMR and mass spectroscopic techniques
%K Mayank R. Mehtaand Satish Batra
%K Anthelmintic activity
%K Antitubercular activity
%K Benzimidazole
%K Benzothiazole
%K Dihydrobenzofuran.
%U https://www.imedpub.com/abstract/dihydrobenzofuran-clubbed-benzimidazole-having-benzothiazole-derivatives-as-potential-anthelmintic-and-antitubercular-agents-11972.html