|
|
Medical Diagnosis 2020
维生素D缺乏与妊娠期糖尿病的研究进展
|
Abstract:
妊娠期糖尿病(GDM)是指在妊娠期间发病或首次发现的任何糖耐量异常，其特点是发病率不断上升。25-羟维生素D(25(OH)D)缺乏已被发现与钙稳态、心血管疾病、肿瘤疾病、感染性疾病和免疫性疾病的发病有关。近年来有研究发现在孕妇中，较低的25-羟维生素D(25(OH)D)缺乏被认为与母亲血糖、胰岛素抵抗和妊娠期糖尿病风险增加有关。该文综述了维生素D与GDM之间的关系研究，为临床工作者在今后GDM患者的管理中提供一定的理论基础。
Gestational diabetes mellitus (GDM) is any glucose tolerance abnormality that develops or is first detected during pregnancy and is characterized by an increasing incidence. 25-hydroxyvitamin D (25 (OH) D) deficiency has been associated with the development of calcium homeostasis, cardio-vascular disease, tumor disease, infectious and immunological diseases. In recent years, studies have found that low levels of 25-hydroxyvitamin D (25 (OH) D) in pregnant women are associated with increased risk of maternal blood sugar, insulin resistance and gestational diabetes. This paper reviews the relationship between vitamin D and GDM to provide a theoretical basis for clinical workers in the management of GDM patients in the future.
| [1] | Holick, M.F. (2009) Vitamin D Status: Measurement, Interpretation, and Clinical Application. Annals of Epidemiology, 19, 73-78. https://doi.org/10.1016/j.annepidem.2007.12.001 |
| [2] | Chiefari, E., Arcidiacono, B., Foti, D., et al. (2017) Gestational Diabetes Mellitus: An Updated Overview. Journal of Endocrinological Investigation, 40, 899-909. https://doi.org/10.1007/s40618-016-0607-5 |
| [3] | Kahn, S.E., Prigeon, R.L., Mcculloch, D.K., et al. (1993) Quantification of the Relationship between Insulin Sensitivity and Beta-Cell Function in Human Subjects. Evidence for a Hyperbolic Function. Diabetes, 42, 1663-1672.
https://doi.org/10.2337/diabetes.42.11.1663 |
| [4] | Senti, J., Thiele, D.K. and Anderson, C.M. (2012) Maternal Vitamin D Status as a Critical Determinant in Gestational Diabetes. Journal of Obstetric, Gynecologic, & Neonatal Nursing, 41, 328-338.
https://doi.org/10.1111/j.1552-6909.2012.01366.x |
| [5] | Kautzky-Willer, A., Prager, R., Waldhausl, W., et al. (1997) Pronounced Insulin Resistance and Inadequate Beta-Cell Secretion Characterize Lean Gestational Diabetes during and after Pregnancy. Diabetes Care, 20, 1717-1723.
https://doi.org/10.2337/diacare.20.11.1717 |
| [6] | Haddad, J.G. and Stamp, T.C. (1974) Circulating 25-Hydroxyvitamin D in Man. The American Journal of Medicine, 57, 57-62. https://doi.org/10.1016/0002-9343(74)90768-2 |
| [7] | Triunfo, S. and Lanzone, A. (2016) Potential Impact of Maternal Vitamin D Status on Obstetric Well-Being. Journal of Endocrinological Investigation, 39, 37-44. https://doi.org/10.1007/s40618-015-0330-7 |
| [8] | Thorne-lyman, A. and Fawzi, W.W. (2012) Vitamin D during Pregnancy and Maternal, Neonatal and Infant Health Outcomes: A Systematic Review and Meta-Analysis. Paediatric and Perinatal Epidemiology, 26, 75-90.
https://doi.org/10.1111/j.1365-3016.2012.01283.x |
| [9] | Hypp？nen, E., L？？r？, E., Reunanen, A., et al. (2001) Intake of Vitamin D and Risk of Type 1 Diabetes: A Birth-Cohort Study. The Lancet, 358, 1500-1503. https://doi.org/10.1016/S0140-6736(01)06580-1 |
| [10] | Cade, C. and Norman, A.W. (1986) Vitamin D3 Improves Impaired Glucose Tolerance and Insulin Secretion in the Vitamin D-Deficient Rat in Vivo. Endocrinology, 119, 84-90. https://doi.org/10.1210/endo-119-1-84 |
| [11] | Bourlon, P.M., Billaudel, B. and Faure-dussert, A. (1999) Influence of Vitamin D3 Deficiency and 1,25 Dihydroxyvitamin D3 on De Novo Insulin Biosynthesis in the Islets of the Rat Endocrine Pancreas. Journal of Endocrinology, 160, 87-95. https://doi.org/10.1677/joe.0.1600087 |
| [12] | 林丽娟. 孕妇血清25-羟维生素D水平检测的临床意义[D]: [硕士学位论文]. 太原: 山西医科大学, 2019. |
| [13] | Wei, S.Q., Qi, H.P., Luo, Z.C., et al. (2013) Maternal Vitamin D Status and Adverse Pregnancy Outcomes: A Systematic Review and Meta-Analysis. Journal of Maternal-Fetal and Neonatal Medicine, 26, 889-899.
https://doi.org/10.3109/14767058.2013.765849 |
| [14] | Poel, Y.H., Hummel, P., Lips, P., et al. (2012) Vitamin D and Gestational Diabetes: A Systematic Review and Meta-Analysis. European Journal of Internal Medicine, 23, 465-469. https://doi.org/10.1016/j.ejim.2012.01.007 |
| [15] | Grant, W.B. (2011) Adequate Vitamin D during Pregnancy Reduces the Risk of Premature Birth by Reducing Placental Colonization by Bacterial Vaginosis Species. Mbio, 2, e00022-11. https://doi.org/10.1128/mBio.00022-11 |
| [16] | Taheri, M., Baheiraei, A., Foroushani, A.R., et al. (2015) Treatment of Vitamin D Deficiency Is an Effective Method in the Elimination of Asymptomatic Bacterial Vaginosis: A Placebo-Controlled Randomized Clinical Trial. Indian Journal of Medical Research, 141, 799-806. https://doi.org/10.4103/0971-5916.160707 |
| [17] | Dunlop, A.L., Taylor, R.N., Tangpricha, V., et al. (2011) Maternal Vitamin D, Folate, and Polyunsaturated Fatty Acid Status and Bacterial Vaginosis during Pregnancy. Infectious Diseases in Obstetrics and Gynecology, 2011, Article ID: 216217. https://doi.org/10.1155/2011/216217 |
| [18] | 刘冬梅, 王肃, 索艳, 等. 妊娠早期维生素D缺乏对妊娠期糖尿病的预测价值及妊娠结局影响[J]. 中国计划生育学杂志, 2018, 26(12): 1179-1182. |
