|
基于机器学习的中医治疗阴黄证用药规律研究
|
Abstract:
目的:利用现代信息技术对传统医学治疗阴黄证的方法进行数据分析,总结提炼中医治疗阴黄证的用药规律。方法:全文检索中国知网、维普、万方等数据库中有关中药治疗阴黄证的文献,构建阴黄证用药数据库,从药物性、味、归经、功效等方面,除频次分析外,采用关联规则、复杂网络、聚类分析等经典机器学习方法对用药规律进行数据挖掘。结果:发现治疗阴黄证以温药为主,药味以甘、辛为主,药物归经以脾经、胃经、肝经为主,揭示了阴黄证病位主要在于肝胆、脾胃。中药聚类可分为三类,分别是温阳利湿、活血化瘀和健脾。结论:中药治疗阴黄证时注重顾护脾阳,药物主要是以茵陈术附汤为主方,兼以健脾和胃、温中补虚、利水渗湿或活血化瘀的药物,本研究可为中后期黄疸及慢性肝炎患者的临床治疗提供理论依据。
Objective: To analyze and summarize the law of Traditional Chinese Medicine (TCM) in treating yin jaundice syndrome. Methods: To search the literature of traditional Chinese medicine treatment of yin jaundice syndrome in the database of CNKI, Weipu and Wanfang, and establish the database of yin jaundice syndrome medication. In addition to frequency analysis, classical machine learning methods such as association rules, complex networks, clustering analysis are used to mine the drug use rules from the aspects of drug properties, taste, meridian tropism and efficacy. Results: It was found that the treatment of yin jaundice syndrome was mainly based on warm drugs, the taste of the medicine was mainly sweet, and pungent, and the drug route was mainly through spleen, stom-ach and liver, revealing that the location of yin jaundice syndrome was mainly in liver and gallbladder, spleen and stomach. TCM clustering can be divided into three categories: Warming Yang and promoting dampness, promoting blood circulation and removing blood stasis, and strengthening spleen. Conclusion: The TCM pays attention to the protection of Spleen Yang in the treatment of yin jaundice syndrome, drugs are mainly Yin Chen Zhu Fu Tang as the main prescrip-tion, and also medicine for strengthening spleen and stomach, warming up deficiency, benefiting water infiltration or promoting blood circulation and removing blood stasis, which provides the ba-sis for clinical treatment of patients with jaundice and chronic hepatitis.
[1] | 刘江凯, 赵文霞. 赵文霞临证治疗黄疸经验浅析[J]. 中华中医药杂志, 2015, 30(11): 3982-3984. |
[2] | 张建军, 张赤志, 张明辉. 阴黄证论及其辨治[J]. 中国医药学报, 2003(11): 679-681. |
[3] | 朱清静, 盛国光. 阴黄理论的形成与证治探讨[J]. 中医研究, 2006, 19(2): 1-3. |
[4] | 朱波, 李桥茹, 贾建伟. 茵陈术附汤加味治疗慢性肝衰竭阴黄证临床效果分析[J]. 内蒙古中医药, 2019, 38(4): 15. |
[5] | 桑培敏, 达呼巴雅尔, 王乐三, 等. 阳黄-阴阳黄-阴黄辨证论治联合西药治疗乙型肝炎相关慢加急性肝衰竭患者生存分析[J]. 中医杂志, 2019, 60(7): 582-586. |
[6] | 梁泳, 李苗, 周诗澜, 黄古叶. 基于方证辨证之茵陈四逆汤治疗慢性乙型肝炎阴黄患者临床观察[J]. 实用肝脏病杂志, 2018, 21(6): 975-976. |
[7] | 陈向明, 李钊成. 茵陈术附汤加味治疗慢性肝衰竭阴黄证临床研究[J]. 深圳中西医结合杂志, 2016, 26(16): 50-51. |
[8] | 肖恒, 胡振斌. 中医药防治黄疸阴黄的研究进展[J]. 大众科技, 2017, 19(12): 64-66. |
[9] | 胡杰, 冯慧, 朱晓云, 刘喜明. 刘喜明辨治糖尿病肾病用药规律分析[J]. 中医药导报, 2019, 25(16): 109-113. |
[10] | 汪玉薇, 解丹. 中医病案数据挖掘现状分析[J]. 医学信息学杂志, 2016, 37(9): 58-61. |
[11] | 王玉忠, 于培龙. 中西医结合治疗慢性肝炎顽固性黄疸临床观察[J]. 临床荟萃, 2005(10): 578-579. |
[12] | 张英凯, 张冰, 张敏. 健软四苓汤联合西药治疗慢性乙型肝炎重度黄疸患者38例临床观察[J]. 中医杂志, 2014, 55(7): 588-590. |