全部 标题 作者
关键词 摘要

OALib Journal期刊
ISSN: 2333-9721
费用：99美元
投递稿件

查看量下载量

相关文章

更多...

Ezrin与Ki-67在软组织肉瘤中的表达与术后复发的关系
Relationship between Ezrin and Ki-67 Expression in Soft Tissue Sarcoma and Postoperative Recurrence

DOI: 10.12677/ACM.2020.109286, PP. 1906-1910

Keywords: 软组织肉瘤，复发，Ezrin蛋白，Ki-67
Soft Tissue Sarcoma, Recurrence, Ezrin Protein, Ki-67

Full-Text   Cite this paper   Add to My Lib

Abstract:

目的：探讨Ezrin与Ki-67在软组织肉瘤中的表达与术后复发的关系。方法：收集2016年7月至2019年4月在青岛大学附属医院接受手术治疗的116例软组织肉瘤患者的临床资料，随访时间至少2年，术后分为复发组(n = 35)和未复发组(n = 81)，分别检测Ezrin及Ki-67蛋白的表达，分析Ezrin阳性与Ki-67阳性与软组织肉瘤术后复发的关系。结果：其中复发组中Ezrin、Ki-67蛋白的阳性表达率分别(85.71%, 74.29%)高于未复发组中Ezrin、Ki-67蛋白的阳性表达率(45.68%, 35.80%)，差异有统计学意义(P < 0.05)。结论：复发组中Ezrin、Ki-67蛋白的阳性表达率分别高于未复发组中Ezrin、Ki-67蛋白的阳性表达率，说明软组织肉瘤术后复发与Ezrin及Ki-67的阳性表达有着密切联系。
Objective: To investigate the relationship between Ezrin and KI-67 expression in soft tissue sarcoma and postoperative recurrence. Methods: Collected data in July 2016 to April 2019 in Qingdao university hospital in patients undergoing surgical treatment of 116 cases of soft tissue sarcoma of the clinical data, at least 2 years of follow-up, postoperative recurrence was divided into groups (n = 35) and group (n = 81), and without recurrence Ezrin and Ki-67 was detected in protein expression, analysis of Ezrin positive and Ki-67 positive relationship with the recurrence of soft tissue sarcomas. Results: The positive expression rates of Ezrin and KI-67 in the recurrent group (85.71%, 74.29%) were higher than that of the non-recurrent group (45.68%, 35.80%), and the difference was statistically significant (P < 0.05). Conclusion: The positive expression rates of Ezrin and KI-67 in the recurrent group were higher than that of the non-recurrent group, indicating that the positive expression of Ezrin and KI-67 was closely related to the postoperative recurrence of soft tissue sarcoma.

References

[1]  中国抗癌协会肉瘤专业委员会, 中国临床肿瘤学会. 软组织肉瘤诊治中国专家共识 (2015年版) [J]. 指南与规范, 2016, 38(4): 310-320.
[2]  Von Mehren, M., Randall, R.L., Benjamin, R.S., et al. (2018) Soft Tissue Sarcoma, Version 2. 2018, NCCN Clinical Practice Guidelines in Oncology. Journal of the National Comprehensive Cancer Network, 16, 536-556.
https://doi.org/10.6004/jnccn.2018.0025
[3]  Edmonson, J.H., Ryan, L.M., Blum, R.H., Brooks, J.S., Shiraki, M. and Parkinson, S.F.R. (1993) Randomized Comparison of Doxorubicin Alone versus Ifosfamide plus Doxorubicin or Mitomycin, Doxorubicin, and Cisplatin against Advanced Soft Tissue Sarcomas. Journal of Clinical Oncology, 11, 1269-1275.
https://doi.org/10.1200/JCO.1993.11.7.1269
[4]  Lee, H., Jo, E.B., Kim, S.J., et al. (2017) Therapeutic Strategies for Locally Recurrent and Metastatic De-Differentiated Liposarcoma with Herpes Simplex Virus-Thymidine Kinase-Expressing Mesenchymal Stromal Cells. Cytotherapy, 19, 1035-1047.
https://doi.org/10.1016/j.jcyt.2017.05.008
[5]  陈丽君, 任晓丽, 孙秀利, 等. p53、p16、PTEN、Ki-67、p63在子宫内膜腺癌中的表达及其与预后的相关性[J]. 中国妇幼健康研究, 2016, 27(9): 1157-1160.
[6]  唐夏莉, 焦德敏, 陈君, 等. miＲNA-126对肺癌A549细胞的增殖、迁移、侵袭及EGFR/AKT/mTOR信号通路的影响[J]. 中国病理生理杂志, 2016, 32(3): 458-463.
[7]  黄东, 刘丹, 孙 敏, 等. 原发性肝癌组织基质金属蛋白酶-9和磷脂酰基醇蛋白聚糖-3表达及临床病理意义[J]. 中华实验外科杂志, 2016, 33(9): 2200-2202.
[8]  Colombo, C., Miceli, R., Le Pechoux, C., Palassini, E., Honoré, C., Stacchiotti, S., Mir, O., Casali, P.G., D？mont, J., Fiore, M., Le Cesne, A., Gronchi, A. and Bonvalot, S. (2015) Sporadic Extra Abdominal Wall Desmoidtype Fibromatosis: Surgical Resection Can Be Safely Limited to a Minority of Patients. European Journal of Cancer, 51, 186-192.
https://doi.org/10.1016/j.ejca.2014.11.019
[9]  AI-Absi, E., Farrokhyar, F., Sharma, R., Whelan, K., Corbett, T., Patel, M. and Ghert, M. (2010) A Systematic Review and Meta-Analysis of Oncologic Outcomes of Pre-Versus Postoperative Radiation in Localized Resectable Soft-Tissue Sarcoma. Annals of Surgical Oncology, 17, 1367-1374.
https://doi.org/10.1245/s10434-009-0885-7
[10]  Li, W., Jin, W.W., Tsuji, K., et al. (2017) Ezrin Directly Interacts with AQP2 and Promotes Its Endocytosis. Journal of Cell Science, 130, 2914-2925.
https://doi.org/10.1242/jcs.204842
[11]  Liang, F., Wang, Y., Shi, L. and Zhang, J.M. (2017) Association of Ezrin Expression with the Progression and Prognosis of Gastrointestinal Cancer: A Meta-Analysis. Oncotarget, 8, 93186-93195.
https://doi.org/10.18632/oncotarget.21473
[12]  Carneiro, A., Bendahl, P.O., Akerman, M., Domanski, H.A., Rydholm, A., Engellau, J. and Nilbert, M. (2011) Ezrin Expression Predicts Local Recurrence and Development of Metastasesin Soft Tissue Sarcomas. Journal of Clinical Pathology, 64, 689-694.
https://doi.org/10.1136/jcp.2011.089805
[13]  Huang, H.Y., Li, C.F., Fang, F.M., Tsai, J.-W., Li, S.-H., Lee Y.-T. and Wei, H.-M. (2010) Prognostic Implication of Ezrin Overexpression in Myxofibrosarcomas. Annals of Surgical Oncology, 17, 3212-3219.
https://doi.org/10.1245/s10434-010-1185-y
[14]  杨杰, 曹毅, 柯瑞盛, 等 . Ki-67和DNA拓扑异构酶IIα表达对原发性肝癌患者肝移植手术预后的价值[J]. 中华 肝胆外科杂志, 2016, 22(10): 687-691.
[15]  黄晓东, 李沛雨, 卢灿荣, 等. 腹膜后脂肪肉瘤切除术后免疫组化标记物MDM2、CDK4、Ki-67 与其预后的关系[J]. 解放军医学院学报, 2016, 37(1): 34-38.

Full-Text

Contact Us

service@oalib.com

QQ:3279437679

WhatsApp +8615387084133