全部 标题 作者
关键词 摘要

OALib Journal期刊
ISSN: 2333-9721
费用:99美元

查看量下载量

相关文章

更多...
-  2018 

Synthesis of catechol

DOI: 10.1177/0883911517734814

Keywords: Temperature-responsive,injectable,hydrogel,tissue adhesive,catechol

Full-Text   Cite this paper   Add to My Lib

Abstract:

Injectable and temperature-sensitive hydrogels were synthesized for use as a tissue-adhesive material between dopamine end-capped Pluronic and CCDP-q-PDB (2-chloro-3′,4′-dihydroxyacetophenone-quaternized poly((dimethyl aminoethyl methacrylate)-co-(t-butylmethacrylate))). The mixture of dopamine end-capped Pluronic and CCDP-q-PDB exists in a viscous solution state at room temperature, but becomes a gel via in situ crosslinking at body temperature. The hydrogel structure was shown to be more stable than Pluronic F127 copolymers in aqueous solution. At a 14:8?wt% ratio of dopamine end-capped Pluronic to CCDP-q-PDB, the sol quickly transformed into a gel at body temperature and under physiological conditions (<10?s), showing excellent gel stability. To evaluate the tissue-adhesive properties, the temperature-sensitive crosslinked dopamine end-capped Pluronic CCDP-q-PDB hydrogels, which can be applied for drug delivery, tissue engineering, and for use as tissue adhesives, were tested using a universal testing machine

Full-Text

Contact Us

service@oalib.com

QQ:3279437679

WhatsApp +8615387084133