%0 Journal Article
%T Synthesis of catechol
%A Eun Bi Kang
%A Insik In
%A Sung Young Park
%A Zihnil Adha Islamy Mazrad
%J Journal of Bioactive and Compatible Polymers
%@ 1530-8030
%D 2018
%R 10.1177/0883911517734814
%X Injectable and temperature-sensitive hydrogels were synthesized for use as a tissue-adhesive material between dopamine end-capped Pluronic and CCDP-q-PDB (2-chloro-3¡ä,4¡ä-dihydroxyacetophenone-quaternized poly((dimethyl aminoethyl methacrylate)-co-(t-butylmethacrylate))). The mixture of dopamine end-capped Pluronic and CCDP-q-PDB exists in a viscous solution state at room temperature, but becomes a gel via in situ crosslinking at body temperature. The hydrogel structure was shown to be more stable than Pluronic F127 copolymers in aqueous solution. At a 14:8£¿wt% ratio of dopamine end-capped Pluronic to CCDP-q-PDB, the sol quickly transformed into a gel at body temperature and under physiological conditions (<10£¿s), showing excellent gel stability. To evaluate the tissue-adhesive properties, the temperature-sensitive crosslinked dopamine end-capped Pluronic CCDP-q-PDB hydrogels, which can be applied for drug delivery, tissue engineering, and for use as tissue adhesives, were tested using a universal testing machine
%K Temperature-responsive
%K injectable
%K hydrogel
%K tissue adhesive
%K catechol
%U https://journals.sagepub.com/doi/full/10.1177/0883911517734814