Mutant p53 talks to proteasomes—is there a feedback loop between Nrf2 and mutant p53?

The p53 protein is a powerful tumor suppressor, often termed as ‘guardian of the genome’, whose function is lost in many types of human cancers (1). The loss of function is impelled either by de-regulation of the E3 ubiquitin ligase, MDM2 protein (2) or by the TP53 gene mutations of missense type (3). Mutations in TP53 gene occur at a very high frequency and range from 10% to 97% depending on the cancer type (4). Single amino acid substitutions result in the loss of tumor suppression transcription function, promote the change of the conformation and loss of the sequence-specific DNA binding function of mutant p53 (mtp53) (5)