%0 Journal Article
%T Mutant p53 talks to proteasomes¡ªis there a feedback loop between Nrf2 and mutant p53?
%A Joanna Zawacka-Pankau
%A Pilar Acedo
%J SCIE-indexed Journal
%D 2016
%R 10.21037/11262
%X The p53 protein is a powerful tumor suppressor, often termed as ¡®guardian of the genome¡¯, whose function is lost in many types of human cancers (1). The loss of function is impelled either by de-regulation of the E3 ubiquitin ligase, MDM2 protein (2) or by the TP53 gene mutations of missense type (3). Mutations in TP53 gene occur at a very high frequency and range from 10% to 97% depending on the cancer type (4). Single amino acid substitutions result in the loss of tumor suppression transcription function, promote the change of the conformation and loss of the sequence-specific DNA binding function of mutant p53 (mtp53) (5)
%U http://tcr.amegroups.com/article/view/11262/html