The effect of delayed adjuvant chemotherapy on relapse of triplenegative breast cancer

Triple-negative breast cancer (TNBC), defined by lacking estrogen receptor (ER), progesterone receptor (PR) expression as well as human epithelial growth receptor 2 (HER2) gene amplification, consist of a group of biologically aggressive and highly proliferative disease. Chemotherapy has been accepted as the mainstay of systemic treatment for TNBC patients, bringing dramatic benefit to both early and late stage TNBC patients (1). But TNBC still has a higher rate of loco-regional and distant recurrence and a worse prognosis than women with other breast cancer subtypes. Optimization in both chemotherapy regimen and how we give them is high priority