Alpha-synuclein overexpression in the olfactory bulb initiates prodromal symptoms and pathology of Parkinson’s disease

Identification of AAV hm-α-Syn expression in the OB. a Nissl stained section showing an example of the OB injection. Arrows point to the precise location of the site of the needle tract. b Representative examples of the GFP labeling patterns from the AAV-hm-α-Syn-GFP and control AAV-GFP injection animals. c Comparison of the numbers of GFP positive cells between the AAV-hm-α-Syn-GFP and control AAV-GFP injected animal