Synergistic inhibition of MEK/ERK and BRAF V600E with PD98059 and PLX4032 induces sodium/iodide symporter (NIS) expression and radioiodine uptake in BRAF mutated papillary thyroid cancer cells

DOI: 10.1186/s13044-018-0057-6

Keywords: Papillary thyroid carcinoma, Assodium/iodide symporter, Mutation BRAFV600E, Mitogen-activated protein kinase

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Abstract:

Western blot of NIS in lysates of BCPAP cells (a) and K1 cells (b) treated with PLX4032 (0.001–0.1 μM) or PD98059 (0.001–0.1 μM) or their combination for indicated time

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