Parental Allergic Diseases Associate with Skin Hypersensitivity to Histamine in Their Infants

Histamine regulates immune response and inflammation, and impairs the skin barrier dysfunction that initiates a clinical manifestation of eczema, and then atopic dermatitis (AD). Using skin prick tests (SPTs) to histamine as a marker of skin hypersensitivity mediated mast cells, we investigated whether parental allergic diseases affect skin hypersensitivity to histamine and skin diseases in their infants.