Human Hemopoietic Progenitor Cell Toll-like and Thymic Stromal Lymphopoietin Receptor Expression and Function in Allergic Asthmatic Subjects

We demonstrated that cord blood human progenitor cells (HPC) from high allergic risk newborns expressed Toll-like receptors (TLR) less abundantly than low allergic risk infants. We also have recently found a key role for thymic stromal lymphopoietin (TSLP) in human eosinophil and basophil differentiation from HPC in allergic subjects. However, TLR or TLR-induced TSLP receptor (TSLPR) expression by HPC has never been studied in allergic asthmatic subjects.