EPIT decreases T1D incidence in sensitized non obese diabetic mice: a likely bystander effect of EPIT-induced Tregs

Epicutaneous immunotherapy (EPIT) has the potency to generate significantly Foxp3+CD62L+ Tregs in mice. In previous published works, we have shown that EPIT-induced Tregs prevent from further sensitizations in sensitized mice. The aim of this study was to highlight the potency of this bystander effect conferred by EPIT-induced Tregs on the treatment of autoimmune disorders such as Type 1 Diabetes (T1D).