Cryj 1, a major allergen of Japanese cedar pollen, up-regulates the effector functions of eosinophils

Japanese cedar pollinosis is the most common form of pollinosis in Japan and has recently remarkably increased. There is evidence that eosinophils play important roles in the development of aggravating the clinical symptoms of the allergic rhinitis or bronchial asthma. In this study, we examined whether Cryj 1, which is the major Japanese cedar pollen allergen, could directly modifies eosinophil functions such as superoxide anion (O2？) generation and adhesion.