Identification of Combinatorial Genomic Abnormalities Associated with Prostate Cancer Early Recurrence

Multiple biomarkers are needed to distinguish aggressive from indolent prostate cancer. We tested the prognostic utility of a three-marker fluorescent in situ hybridization (FISH) panel (TMPRSS2/ERG rearrangements, AR gain, and PTEN deletion) in a retrospective cohort (n = 210; median follow-up, 5.7 years). PTEN deletion was associated with an increased risk of biochemical recurrence (BcR; hazard ratio, 3.58; 95% CI, 1.39–9.22; P？<？0.01) by multivariable Cox regression analyses and earlier BcR (P？<？0.02) by Kaplan-Meier analysis.