%0 Journal Article
%T Identification of Combinatorial Genomic Abnormalities Associated with Prostate Cancer Early Recurrence
%A Christopher Porter
%A Claudio Jeldres
%A Cynthia Friedman
%A Lena Glaskova
%A Min Fang
%A Peter S. Nelson
%A Sarah Schroeder
%A Xiaoyu Qu
%J The Journal of Molecular Diagnostics
%D 2016
%R 10.1016/j.jmoldx.2015.10.001
%X Multiple biomarkers are needed to distinguish aggressive from indolent prostate cancer.
We tested the prognostic utility of a three-marker fluorescent in situ hybridization
(FISH) panel (TMPRSS2/ERG rearrangements, AR gain, and PTEN deletion) in a retrospective
cohort (n = 210; median follow-up, 5.7 years). PTEN deletion was associated with an
increased risk of biochemical recurrence (BcR; hazard ratio, 3.58; 95% CI, 1.39¨C9.22;
P£¿<£¿0.01) by multivariable Cox regression analyses and earlier BcR (P£¿<£¿0.02) by Kaplan-Meier
analysis.
%U https://jmd.amjpathol.org/article/S1525-1578(15)00256-1/fulltext