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-  2017 

Mesenchymal Stem Cell-Dependent Modulation of Liver Diseases

DOI: 10.7150/ijbs.20240

Keywords: mesenchymal stem cells, immune response, acute liver failure, cirrhosis, therapy.

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Abstract:

Acute liver failure and cirrhosis display sequential and overlapping severe pathogenic processes that include inflammation, hepatocyte necrosis, and fibrosis, carrying a high mortality rate. Mesenchymal stem cells (MSCs) are a heterogeneous subset of stromal stem cells with immunonodulatory characteristics. MSCs are considered to act through multiple mechanisms to coordinate a dynamic, integrated response to liver inflammation and fibrosis, which prevents the progressive distortion of hepatic architecture. Accordingly, MSCs as well as their products have been investigated as a novel therapeutic approach for the treatment of inflammatory and fibrotic liver diseases.

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