%0 Journal Article
%T Mesenchymal Stem Cell-Dependent Modulation of Liver Diseases
%A Aleksandar Arsenijevic
%A Ana Volarevic
%A Bojana Simovic Markovic
%A Ivanka Dimova
%A Marina Gazdic
%A Miodrag Stojkovic
%A Nebojsa Arsenijevic
%A Valentin Djonov
%A Vladislav Volarevic
%J International Journal of Biological Sciences
%D 2017
%R 10.7150/ijbs.20240
%X Acute liver failure and cirrhosis display sequential and overlapping severe pathogenic processes that include inflammation, hepatocyte necrosis, and fibrosis, carrying a high mortality rate. Mesenchymal stem cells (MSCs) are a heterogeneous subset of stromal stem cells with immunonodulatory characteristics. MSCs are considered to act through multiple mechanisms to coordinate a dynamic, integrated response to liver inflammation and fibrosis, which prevents the progressive distortion of hepatic architecture. Accordingly, MSCs as well as their products have been investigated as a novel therapeutic approach for the treatment of inflammatory and fibrotic liver diseases.
%K mesenchymal stem cells
%K immune response
%K acute liver failure
%K cirrhosis
%K therapy.
%U http://www.ijbs.com/v13p1109.htm