FH检测在直肠恶性肿瘤早期筛查中的诊断价值
DOI: 10.3971/j.issn.1000-8578.2019.18.1236
Keywords: A Meta-analysis,Effects of Antisense Oligonucleotides Against miRNA-21 on Growth of Human Colon Cancer Cells in vivo,Effects of NDUFA4 Overexpression on Growth of Human Colon Cancer Cells in vitro,Role of Diffusion-weighted Magnetic Resonance Imaging in Forecasting Curative Effect of Preoperative Chemoradiotherapy on Locally Advanced Rectal Cancer,Application of Carbon Nanoparticles in Da Vinci Radical Resection of Rectal Carcinoma,New Pattern of Rectal Cancer Treatment: Total Neoadjuvant Therapy,Influence of TYMP Polymorphism on Clinical Outcomes of Colorectal Cancer Patients Received Adjuvant Chemotherapy After R0 Resection,Established of Serum Diagnostic Model for Colorectal Cancer Patients Using MB-WCX and MALDI-TOF MS,Perioperative Outcomes Between Laparoscopic and Conventional Open Lateral Pelvic Lymph Node Dissection following Total Mesorectal Excision for Mid-low Rectal Cancer,Concept and Technological Innovation Push Forward Minimally Invasive Surgery on Colorectal Cancer,Effect of Food Intake on Risk of Rectal Cancer: A Meta-analysis,Differential Expressions of microRNAs in Rectal Adenocarcinoma Tissues,Effect of Hypoxia and HIF-1α on Epithelial-mesenchymal Transition,Invasion and Proliferation in Colorectal Cancer,Surgical Strategy for Patients with Rectal Carcinoma,Indication and Influencing Factors of Local Excision for Rectal Cancer
Abstract:
摘要 目的 探讨直肠上皮细胞稳定性FH检测在直肠恶性肿瘤早期筛查中的诊断价值。方法 300例被检者均行直肠上皮细胞稳定性FH、CEA和CA19-9检测。以病理学诊断结果为金标准，辅以电子结肠镜检查，分析上皮细胞稳定性FH、CEA和CA19-9检测对直肠恶性肿瘤筛查的敏感度、特异性、假阴性率（漏诊率）、假阳性率（误诊率）、阴性似然比、阳性似然比、诊断指数、约登指数、粗符合率、阴性预测值、阳性预测值等指标。结果 经上皮细胞稳定性FH检测直肠恶性肿瘤患者阳性率高于CEA和CA19-9检测（P=0.000）。40例直肠恶性肿瘤患者中上皮细胞稳定性FH检测出阳性患者38例（95%），CEA检测出阳性患者23例（57.50%），CA19-9检测出阳性患者10例（25.00%）。上皮细胞稳定性FH检测的敏感度、阳性似然比、诊断指数、约登指数、阴性预测值、阳性预测值均高于CEA和CA19-9检测，假阴性率和阴性似然比均低于CEA和CA19-9检测。结论 上皮细胞稳定性FH检测在直肠恶性肿瘤筛查中检测结果有较高的敏感度、阳性似然比、诊断指数、约登指数、阴性预测值、阳性预测值，较低的假阴性率和阴性似然比
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