%0 Journal Article
%T FH检测在直肠恶性肿瘤早期筛查中的诊断价值
%A 戚文月
%A 郭亚苹
%A 郭虹君
%A 马茜
%A 高策
%A 高记华
%A 黄晓明
%J 肿瘤防治研究
%D 2019
%R 10.3971/j.issn.1000-8578.2019.18.1236
%X 摘要 目的 探讨直肠上皮细胞稳定性FH检测在直肠恶性肿瘤早期筛查中的诊断价值。方法 300例被检者均行直肠上皮细胞稳定性FH、CEA和CA19-9检测。以病理学诊断结果为金标准，辅以电子结肠镜检查，分析上皮细胞稳定性FH、CEA和CA19-9检测对直肠恶性肿瘤筛查的敏感度、特异性、假阴性率（漏诊率）、假阳性率（误诊率）、阴性似然比、阳性似然比、诊断指数、约登指数、粗符合率、阴性预测值、阳性预测值等指标。结果 经上皮细胞稳定性FH检测直肠恶性肿瘤患者阳性率高于CEA和CA19-9检测（P=0.000）。40例直肠恶性肿瘤患者中上皮细胞稳定性FH检测出阳性患者38例（95%），CEA检测出阳性患者23例（57.50%），CA19-9检测出阳性患者10例（25.00%）。上皮细胞稳定性FH检测的敏感度、阳性似然比、诊断指数、约登指数、阴性预测值、阳性预测值均高于CEA和CA19-9检测，假阴性率和阴性似然比均低于CEA和CA19-9检测。结论 上皮细胞稳定性FH检测在直肠恶性肿瘤筛查中检测结果有较高的敏感度、阳性似然比、诊断指数、约登指数、阴性预测值、阳性预测值，较低的假阴性率和阴性似然比
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%U http://www.zlfzyj.com/CN/abstract/abstract9378.shtml