谷氨酰胺转运载体ASCT2在肿瘤中的研究进展
DOI: 10.3971/j.issn.1000-8578.2019.18.1149
Keywords: A Scientometric Analysis,A Case Report of Four Primary Malignant Tumors,Advances in Role of Cyclooxygenase 2 in Development and Progression of Cancer,Dedifferentiated Liposarcoma of Testis: A Case Report and Literature Review,Diffusion-weighted Magnetic Resonance Imaging Evaluates Salivary Gland Function Damage in Nasopharyngeal Carcinoma Patients Treated with Intensity-modulated Radiation Therapy,Research Advances on Effect of Adipose-derived Stem Cells on Biological Characteristics of Breast Cancer,Advances of 125I Radioactive Particle Chain Intracavitary Brachytherapy,Expression of Infiltrating NK Cell Surface Receptors in Peripheral Blood and Cancer Tissues of Patients with Esophageal Squamous Cell Carcinoma,Risk Factors of Pathological Upstaging for Patients with Clinical T2N0M0 Esophageal Squamous Cell Carcinoma,Progress of Stimulation Response Strategy Based on Nanomaterials in Tumor Therapy,Advances in Molecular Mechanisms of Early Bone Metastasis,Diagnostic Value of Peripheral Blood NLR and PLR in Gastrointestinal Pancreatic Neuroendocrine Neoplasm,Advances of Ribonucleotide Reductase Inhibitors on Cancer
Abstract:
摘要 肿瘤细胞具有独特的代谢需求，其代谢过程需要消耗大量的谷氨酰胺。谷氨酰胺与肿瘤细胞的增殖密切相关，它可以调节细胞的存活、代谢、信号转导、自噬等。丙氨酸-丝氨酸-半胱氨酸转运载体2（alanine-serine-cysteine transporter 2, ASCT2）是Na+依赖性的，主要通过跨膜转运谷氨酰胺及一些大分子中性氨基酸。ASCT2在许多肿瘤细胞中都是过度表达的，且ASCT2的高表达与肿瘤患者的不良预后呈正相关。目前国外已将谷氨酰胺的代谢和转运载体作为治疗靶标，进行抗肿瘤新药的研发，但国内对谷氨酰胺转运载体的相关研究报道较少，故本文就ASCT2的结构、表达及在肿瘤中的作用等作一综述
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