%0 Journal Article
%T 谷氨酰胺转运载体ASCT2在肿瘤中的研究进展
%A 王雅乐
%A 黄承浩
%J 肿瘤防治研究
%D 2019
%R 10.3971/j.issn.1000-8578.2019.18.1149
%X 摘要 肿瘤细胞具有独特的代谢需求，其代谢过程需要消耗大量的谷氨酰胺。谷氨酰胺与肿瘤细胞的增殖密切相关，它可以调节细胞的存活、代谢、信号转导、自噬等。丙氨酸-丝氨酸-半胱氨酸转运载体2（alanine-serine-cysteine transporter 2, ASCT2）是Na+依赖性的，主要通过跨膜转运谷氨酰胺及一些大分子中性氨基酸。ASCT2在许多肿瘤细胞中都是过度表达的，且ASCT2的高表达与肿瘤患者的不良预后呈正相关。目前国外已将谷氨酰胺的代谢和转运载体作为治疗靶标，进行抗肿瘤新药的研发，但国内对谷氨酰胺转运载体的相关研究报道较少，故本文就ASCT2的结构、表达及在肿瘤中的作用等作一综述
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%U http://www.zlfzyj.com/CN/abstract/abstract9361.shtml