碱基切除修复因子SmuG1与肿瘤的研究进展
DOI: 10.3971/j.issn.1000-8578.2019.19.0236
Keywords: A Scientometric Analysis,A Case Report of Four Primary Malignant Tumors,Advances in Role of Cyclooxygenase 2 in Development and Progression of Cancer,Dedifferentiated Liposarcoma of Testis: A Case Report and Literature Review,Diffusion-weighted Magnetic Resonance Imaging Evaluates Salivary Gland Function Damage in Nasopharyngeal Carcinoma Patients Treated with Intensity-modulated Radiation Therapy,Research Advances on Effect of Adipose-derived Stem Cells on Biological Characteristics of Breast Cancer,Advances of 125I Radioactive Particle Chain Intracavitary Brachytherapy,Expression of Infiltrating NK Cell Surface Receptors in Peripheral Blood and Cancer Tissues of Patients with Esophageal Squamous Cell Carcinoma,Risk Factors of Pathological Upstaging for Patients with Clinical T2N0M0 Esophageal Squamous Cell Carcinoma,Progress of Stimulation Response Strategy Based on Nanomaterials in Tumor Therapy,Advances in Molecular Mechanisms of Early Bone Metastasis,Diagnostic Value of Peripheral Blood NLR and PLR in Gastrointestinal Pancreatic Neuroendocrine Neoplasm,Advances of Ribonucleotide Reductase Inhibitors on Cancer
Abstract:
摘要 肿瘤是严重威胁人类健康的疾病之一。随着研究的不断深入，人们发现DNA损伤在肿瘤发生发展中的作用不可忽视。DNA损伤发生后，机体识别损伤类型并启动相应的修复机制以维持机体的正常状态，其中DNA糖基化酶SmuG1作为碱基切除修复途径的关键启动蛋白，在保持真核生物的基因稳定性和遗传完整性中发挥重要作用。近年研究发现SmuG1在肿瘤组织中的异常表达，与肿瘤的病理类型、肿瘤细胞的侵袭转移以及患者生存率、药物耐药性均相关。SmuG1有望成为新的肿瘤标志物和潜在治疗靶点
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