%0 Journal Article
%T 碱基切除修复因子SmuG1与肿瘤的研究进展
%A 彭冬先
%A 王观凤
%A 郑丽娇
%A 黄洁
%J 肿瘤防治研究
%D 2019
%R 10.3971/j.issn.1000-8578.2019.19.0236
%X 摘要 肿瘤是严重威胁人类健康的疾病之一。随着研究的不断深入，人们发现DNA损伤在肿瘤发生发展中的作用不可忽视。DNA损伤发生后，机体识别损伤类型并启动相应的修复机制以维持机体的正常状态，其中DNA糖基化酶SmuG1作为碱基切除修复途径的关键启动蛋白，在保持真核生物的基因稳定性和遗传完整性中发挥重要作用。近年研究发现SmuG1在肿瘤组织中的异常表达，与肿瘤的病理类型、肿瘤细胞的侵袭转移以及患者生存率、药物耐药性均相关。SmuG1有望成为新的肿瘤标志物和潜在治疗靶点
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%U http://www.zlfzyj.com/CN/abstract/abstract9461.shtml