靶向CCL2-CCR2轴的肿瘤治疗研究进展
DOI: 10.3971/j.issn.1000-8578.2019.18.1237
Keywords: A Meta-analysis,Efficacy of 93 Cases of Recurrent Ovarian Cancer,Meta-analysis of Efficacy and Safety of Jinlong Capsule Combined with Chemoradiotherapy on Liver Metastases,New Targets for Molecular Therapy of Biliary Malignant Tumors,Global Status and Trends of Tumor Hypoxia: A Scientometric Analysis,A Case Report of Four Primary Malignant Tumors,Clinicopathologic Characteristics and Prognosis of De Novo Metastatic Breast Cancer Patients,Advances in Role of Cyclooxygenase 2 in Development and Progression of Cancer,Dedifferentiated Liposarcoma of Testis: A Case Report and Literature Review,Bone Metastasis in Children with Metanephric Adenosarcoma: A Case Report and Literature Review#br#,Diffusion-weighted Magnetic Resonance Imaging Evaluates Salivary Gland Function Damage in Nasopharyngeal Carcinoma Patients Treated with Intensity-modulated Radiation Therapy,Research Advances on Effect of Adipose-derived Stem Cells on Biological Characteristics of Breast Cancer,Advances of 125I Radioactive Particle Chain Intracavitary Brachytherapy,Expression of Infiltrating NK Cell Surface Receptors in Peripheral Blood and Cancer Tissues of Patients with Esophageal Squamous Cell Carcinoma
Abstract:
摘要 单核细胞趋化蛋白-1（MCP-1/CCL2）是CC类趋化因子家族成员之一。CCL2作用广泛，主要结合CC类趋化因子受体2（CCR2）趋化单核细胞、巨噬细胞和T淋巴细胞。许多研究表明CCL2-CCR2轴参与肿瘤细胞生长存活、血管生成、肿瘤侵袭和转移的调控。本文综述了CCL2-CCR2轴在前列腺癌、乳腺癌、肝癌等肿瘤发生、发展、转移的作用和临床前动物模型实验以及靶向CCL2-CCR2轴的肿瘤治疗临床试验的进展、前景和挑战
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