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DOI: 10.3971/j.issn.1000-8578.2019.18.1961
Keywords: Three Cases Report and Literature Review,High-doses Granulocyte Colony-stimulating Factor (G-CSF) Benefit Elderly Patients with Acute Myeloid Leukemia,Expression of miR-155/PTEN Axis in Hepatocellular Carcinoma and Its Mechanism,Leukemia with Solid Tumor: A Case Report and Literature Review,Myelogenous Blast Crisis of Chronic Myeloid Leukemia(CML-BC) with Complex Karyotype and T Lymphocyte Lymphoma/Leukemia: A Case Report and Literature Review,Mixed-phenotype Acute Leukemia Developed by Chronic Myelogenous Leukemia: A Case Report and Literature Review,Trends of Leukemia Mortality in Kunshan City, Jiangsu Province from 1993 to 2014,Relationship of Expression Difference of miR-658 and miR-492 with Pelvic Lymph Node Metastasis from Squamous Carcinoma of Cervix,Effect of ΔNp63α on Leukemia Inhibitory Factor Expression in Cervical Cancer Cells and Related Mechanism,Research Progress of Relationship Between Urokinase Plasminogen Activator System and Acute Myelocytic Leukemia,Reversion Impact of Peptide Extract from Scorpion Venom on Multidrug-resistance of Leukemia Stem Cell Line K562/A02 in vivo,NOTCH1 Down-regulates Tumor Suppressor Gene ID4 in T-cell Acute Lymphoblastic Leukemia,Targeted Therapy with Sorafenib for FLT3-ITD-positive Acute Myeloid Leukemia Patients
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摘要 外泌体（exosomes）是一类直径介于30~150 nm之间的双层结构的微小囊泡，可由多种类型细胞分泌，内含丰富的蛋白质、mRNA和microRNA，参与细胞间物质交换和信号转导。外泌体通过影响细胞增殖、凋亡和自噬、调节骨髓微环境、促进血管生成以及抑制骨髓造血等多方面促进白血病的发生发展，影响白血病的耐药；同时可作为白血病药物治疗的作用靶点等。本文就外泌体的组成、形成和近年来肿瘤来源的外泌体在白血病中的作用研究进行综述
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